[回想皮膚科學]假性紫質症（pseudoporphyria）

假性紫質症（pseudoporphyria）是一種會出現水泡，很類似緩發性皮膚病變紫質症（porphyria cutanea tarda）的皮膚病，往往跟某些藥物與長期血液透析（洗腎）有關。只要能回答下列六個問題，皮專考試就考不倒了！

Questions	Answers
What are typical s/s of pseudoporphyria	Tense bullae, skin fragility, & erythema on sun-exposed skin
Which type of porphyria is most similar to pseudoporphyria?	Porphyria cutanea tarda(PCT)
What are the differences between PCT & pseudoporphyria	Pseudoporphyria: NO hypertrichosis, hyperpigmentation, & sclerodermoid changes NO festooned, catapillar bodies, & PAS(+) material around vessels Normal or mildly abnormal porphyria profile
What is the cause of pseudoporphyria?	Drugs: normal porphyria profile Long-term hemodialysis: mildly abnormal porphyria profile(2-4X)
What drugs can cause pseudoporphyria?	Naproxen, Nalidixic acid, Furosemide, Pyridoxine,Isotretinoin, & Tetracycline
How to remember the culprits(drugs) causing pseudoporphyria?	NF PIT (NeuroFibroma had the button sign, can become a PIT when pressed.)